عنوان مقاله [English]
Antimicrobial resistance of bacteria is one of the greatest challenges that threatens human health. In order to introduce new compounds with antibacterial effects, two derivatives of ninhydrin-pyroglycol adducts were synthesized by condensation reaction in an ionic liquid as a green solvent and their effects on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa isolated from hospitalized patients in Taleghani Hospital was investigated. To determine the lowest bacterial growth inhibitory concentration (MIC) broth micro-dilution method was used. Chloramphenicol was used as standard antibiotic. Comparison of the results of two synthetic samples showed that pyrogallol-ninhydrin adduct 1:1 versus the above bacteria was superior to pyrogallol-ninhydrin adduct 1:2. Synergistic antibacterial effects study of 200 µg/ml of pyrogallol-ninhydrin adduct 1:2 or 100 µg/ml of pyrogallol-ninhydrin adduct 1:1 plus chloramphenicol series, showed that the concentration of chloramphenicol growth inhibitors decreased to 50 µg/ml.